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目的探讨儿童手足口病血液学变化及临床特征。方法选取2010年1月～2011年12月期间某院儿科诊治的手足口病患儿127例做为观察对象(手足口病组),随机选取保健科同期进行体检的正常儿童120例作为对照样本(正常组),进行血细胞检测,并且分析临床特征。结果 (1)临床特征分析:发热占85.04%,皮疹占80.31%,疱疹占32.28%,呼吸道症状占40.95%,消化道症状者占29.92%,神经系统症状者占11.02%;(2)血液学变化:手足口病组白细胞计数、淋巴细胞、外周淋巴细胞绝对值分别为(16.03±2.87)×109/L、(36.44±16.21)%、(5.81±2.28)×%,高于正常组(7.58±2.01)×109/L、(45.52±6.35)%、(3.25±1.21)×%,比较差异有统计学意义(P﹤0.05)。结论手足口病患儿血液学变化主要表现为淋巴细胞下降,外周淋巴细胞绝对值升高,白细胞升高。
Objective To investigate the hematological changes and clinical features of hand-foot-mouth disease in children. Methods A total of 127 children with hand-foot-mouth disease diagnosed and treated in a hospital from January 2010 to December 2011 were selected as the observation group (HFMD group). 120 healthy children (Normal group), blood cell detection was performed, and clinical features were analyzed. Results (1) Analysis of clinical features: fever accounted for 85.04%, rash accounted for 80.31%, herpes accounted for 32.28%, respiratory symptoms accounted for 40.95%, gastrointestinal symptoms accounted for 29.92%, neurological symptoms accounted for 11.02%; (2) hematology The changes of leukocyte counts, lymphocytes and peripheral lymphocytes in HFMD group were (16.03 ± 2.87) × 109 / L, (36.44 ± 16.21)% and (5.81 ± 2.28)%, respectively, which were higher than those in normal group ± 2.01) × 109 / L, (45.52 ± 6.35)% and (3.25 ± 1.21)% respectively. There was significant difference between the two groups (P <0.05). Conclusion The main changes of hematology in children with HFMD are the decrease of lymphocytes, the increase of the absolute value of peripheral lymphocytes and the increase of white blood cells.