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目的:了解我院药品不良反应(ADR)发生的原因及特点,为临床合理用药提供参考。方法:利用全国不良反应监测网络数据库Excel表格汇总我院2007～2010年上报不良反应507例ADR,分析患者年龄、性别、用药过程及不良反应发生情况。结果:507例患者中,男266例,女241例;>65岁患者32例,<18岁患者180例;涉及药品145种;怀疑单药462例,怀疑联合用药45例。抗微生物药引起的ADR居首位,占68.52%;皮肤及软组织损害最多,占54.56%;静脉给药是发生ADR的主要途径。结论:加强ADR监测,保证用药安全、合理、有效。
Objective: To understand the causes and characteristics of adverse drug reaction (ADR) in our hospital and provide a reference for clinical rational drug use. Methods: A total of 507 cases of adverse reactions were reported in our hospital from 2007 to 2010 by using the National Adverse Reaction Monitoring Network Database Excel. The patients’ age, sex, medication course and adverse reactions were analyzed. Results: There were 266 males and 241 females in 507 cases, 32 cases were> 65 years old, 180 cases were less than 18 years old, 145 were drugs, 462 cases were suspected of single drug and 45 cases were suspected of combination therapy. Anti-microbial drug-induced ADR ranked first, accounting for 68.52%; skin and soft tissue damage the most, accounting for 54.56%; intravenous administration is the main way of ADR. Conclusion: To strengthen the monitoring of ADR to ensure the safety of drugs is reasonable and effective.