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据胰岛素强化治疗疗程,将初诊T2DM患者120例随机分为15天、30天、60天、90天4组,观察治疗后血糖及胰岛β细胞功能改善情况。结果4组患者治疗后血糖良好控制,胰岛β细胞功能明显好转,60天组、90天组胰岛β细胞早时相分泌指标、胰岛素抵抗指标改善更显著。结论胰岛素强化治疗15天可改善胰岛β细胞晚相分泌,30天可进一步改善早时相分泌,改善胰岛素抵抗。
120 cases of newly diagnosed T2DM patients were randomly divided into 4 groups of 15 days, 30 days, 60 days and 90 days according to the therapy of insulin intensive treatment. The improvement of blood glucose and islet β-cell function was observed after treatment. Results After treatment, the blood glucose was well controlled and the function of pancreatic β cells was improved in the 4 groups. The early phase secretion index and the insulin resistance index of 60 days group and 90 days group were significantly improved. Conclusion Insulin fortification treatment for 15 days can improve the late phase secretion of pancreatic β cells, 30 days can further improve the early phase secretion, improve insulin resistance.