乳腺癌C-erb B-2癌基因与雌、孕激素受体的关系及预后意义

• 作 者: 幸天勇 杨金巧 周蕾蕾
• 机 构: 华西医科大学附属第一医院普外科,四川省人民医院普外科
• 出 处: 中国普外基础与临床杂志
• 发表日期: 1999年01期
• 关键词: 乳腺癌肿瘤 C-erb B-2 孕激素受体 癌基因 预后意义 雌激素受体 腋窝淋巴结 常规病理检查 石蜡标本 独立预后因素

用ＬＳＡＢ免疫组织化学法检测２４５例乳腺癌石蜡标本ＣｅｒｂＢ２癌基因的表达。结果显示：该癌基因的过度表达与乳腺癌的临床分期晚、组织学分级高、腋窝淋巴结有转移、雌、孕激素受体缺乏及预后差有关。该癌基因的表达是乳腺癌中腋淋巴结状况之外的又一个独立预后因素。该基因表达的检测作为乳腺癌常规病理检查，可用于判断乳腺癌的预后及拟定术后治疗方案

LSAB immunohistochemistry was used to detect the expression of CerbB2 oncogene in 245 paraffin-embedded breast cancer specimens. The results showed that overexpression of this oncogene was associated with late clinical stage, high histological grade, metastasis of axillary lymph nodes, lack of estrogen and progesterone receptors, and poor prognosis. The expression of this oncogene is another independent prognostic factor beyond the axillary lymph node status in breast cancer. The detection of this gene expression as a routine pathological examination of breast cancer can be used to determine the prognosis of breast cancer and to develop a postoperative treatment plan