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1978年White和Lietman复习了地高辛用于因VSD(室间隔缺损)引起的大量左向右分流婴儿的文献。他们发现地高辛用于这些患儿的原理不清。争论的原因是因为测量VSD患儿的心肌收缩力为正常,而仅根据传统的临床经验,支持地高辛常规用于称为“心衰”的状况。毛地黄治疗续发于不发绀的充血性心衰患儿,以前报告其疗效仅60%。争论点是地高辛有无影响心肌收缩力的作用。在心室开始收缩、二尖瓣关闭后,主动脉瓣开放前,通过VDS血液离开心室,这样缺乏真正的等客收缩期,影响了对VSD的心肌收缩力的评价。另外,前后负
1978 White and Lietman reviewed digoxin for VSD (ventricular septal defect) caused a large number of left-right shunt infants literature. They found that digoxin was not clear for these children. The argument arose because measuring myocardial contractility in children with VSD was normal, and based only on traditional clinical experience, supporting digoxin was routinely used in conditions known as “heart failure.” Foxglove treatment of non-cyanotic patients with congestive heart failure, previously reported only 60% of its efficacy. The debate is whether digoxin has effects on myocardial contractility. Contraction of the ventricle in the ventricle, mitral valve closure, the aortic valve opening before leaving the ventricle through the VDS blood, so the lack of true islet contraction, affecting the evaluation of VSD myocardial contractility. In addition, before and after negative