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本文观察了4种老年疾病患者的 HPAA 活动及相关肽 NPY 水平与外周血 T 细胞分裂原反应性的关系.结果表明,脑出血、脑梗塞患者 HPAA 活动增强,并与 NPY 水平增加呈伴随关系,HPAA、NPY与受抑的 T 细胞分裂原反应性呈负相关(P<0.01)。糖尿病患者 NPY、CRF、ACTH 含量与健康人比较无明显差异,皮质醇水平升高(P<0.05),后者与受抑的 T 细胞分裂原反应性无明显相关(P>0.05)。而原发性高血压疾病患者 HPAA 及 NPY、T 细胞分裂原反应性与健康者比较均无明显差异(P>0.05).上述资料提示,老年疾患 HPAA 活动及 NPY 水平因病种而异,其中脑血管意外患者的免疫功能变化与 HPAA 活动及 NPY水平有关.
In this paper, we observed the relationship between HPAA activities and NPY levels and peripheral blood T-cell mitogenic reactivities in four kinds of elderly patients.The results showed that HPAA activity in patients with cerebral hemorrhage and cerebral infarction was increased and accompanied by the increase of NPY level, HPAA, NPY negatively correlated with suppressed T cell mitogenic reactivity (P <0.01). The levels of NPY, CRF and ACTH in diabetic patients showed no significant difference compared with those in healthy subjects, and the levels of cortisol increased (P <0.05). The latter had no significant correlation with the deparaffin cell reactivity (P> 0.05). There were no significant differences in the HPAA, NPY and T cell mitotic reactivity between healthy controls and patients with essential hypertension (P> 0.05) .The above data suggest that the activity of HPAA and the level of NPY in elderly patients are different according to the type of disease Changes in immune function in patients with cerebrovascular accident and HPAA activity and NPY levels.