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奥沙利铂是第三代铂类抗肿瘤药，在临床中已广泛应用。大剂量亚叶酸钙（highdosecalciumfolinate，HD－CF）＋５－氟尿嘧啶（５－fluorouracil，５－FU）持续静脉滴注４８h治疗晚期结直肠癌已取得良好的效果犤１，２犦。为探讨奥沙利铂联合HD－CF＋５－FU持续静脉滴注４８h方案
Oxaliplatin is the third generation of platinum antineoplastic agents, which have been widely used clinically. High dose of high-dose calcium folinate (HD-CF) + 5-fluorouracil (5-FU) continuous intravenous infusion of 48h treatment of advanced colorectal cancer has achieved good results 犤 1,2 犦. To investigate the continuous intravenous infusion of oxaliplatin combined with HD-CF + 5-FU for 48 hours