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目的：了解衡阳地区近年来伤寒杆菌耐药情况及治疗伤寒的最有效药物。方法：对本院近２ａ临床分离的１０８株伤寒杆菌用１２种抗菌药物作体外药敏（纸片法）试验。结果：对复方磺胺甲唑、氨苄西林高度耐药；对氟罗沙星、氧氟沙星、环丙沙星、洛美沙星、头孢噻肟耐药率低，对氯霉素和庆大霉素耐药率比既往资料有下降；对阿米卡星、诺氟沙星、头孢哌酮均不同程度耐药。结论：除诺氟沙星外的氟喹诺酮类目前是治疗伤寒最有效药物。近年伤寒杆菌对多年不用的氯霉素、庆大霉素敏感性有所恢复。儿童伤寒宜用头孢噻肟治疗。
OBJECTIVE: To understand the drug resistance of typhoid bacillus in Hengyang in recent years and the most effective drug to treat typhoid fever. Methods: A total of 108 strains of Salmonella typhi isolated in recent 2 years were treated with 12 kinds of antibacterial drugs in vitro (paper method). Results: The drug was highly resistant to sulfamethoxazole and ampicillin, and the drug resistance to fleroxacin, ofloxacin, ciprofloxacin, lomefloxacin and cefotaxime was low, Resistance rate than the previous data have declined; amikacin, norfloxacin, cefoperazone were resistant to varying degrees. CONCLUSIONS: Fluoroquinolones other than norfloxacin are currently the most effective drugs for the treatment of typhoid fever. Salmonella typhi in recent years do not have many years of chloramphenicol, gentamicin sensitivity has been restored. Child typhoid should use cefotaxime treatment.