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目的利用放射性药物思通宁发射的β射线辐射作用引起肿瘤组织内毛细血管扩张,水肿,炎细胞浸润;致死肿瘤细胞而发挥治疗作用。方法采用安盛科兴药业有限公司生产的思通宁111MBq静脉注射治疗,它具有亲骨性,在肿瘤骨转移灶或肿瘤部位出现较高的浓聚,在肿瘤转移灶积药量是正常骨的2～25倍。结果对25例肿瘤骨转移接受治疗后观察,有20例疼痛显著缓解。血清碱性磷酸酶降低,相关肿瘤标志物(如PSA)下降。患者饮食量增加,睡眠时间延长。结论思通宁治疗肿瘤骨转移疼痛在规范的护理指导下,25例中有20例疼痛缓解明显,病情明显好转,生活质量显著提高。
Objective The use of radiopharmaceutical thinking radium emission caused by beta radiation caused by capillary expansion within the tumor tissue, edema, inflammatory cell infiltration; death of tumor cells and play a therapeutic role. Methods AXA Kexing Pharmaceutical Co., Ltd. Sitong Ning 111MBq intravenous injection treatment, it has a pro-bone, the tumor bone metastasis or tumor sites showed a higher concentration, the tumor metastasis volume plot is normal Bone 2 to 25 times. Results Twenty-five cases of bone metastases were observed after treatment, and 20 cases of pain were significantly relieved. Serum alkaline phosphatase is reduced and associated tumor markers such as PSA are decreased. Patients increased diet, sleep time extended. Conclusion Sitangning treatment of tumor pain in bone metastases under the guidance of normative care, 25 cases of pain relief in 20 cases significantly improved the condition significantly improved quality of life.