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在长期游泳训练的大鼠心肌组织中，观察了ＡＲⅡ（心肌局部血管紧张素Ⅱ）的促细胞肥大效应与ＭＡＰＫ（丝裂素活化蛋白激酶）活性的关系，以探讨ＡＴⅡ促进运动心肌肥大的信息传递机制。结果表明：运动组心系数增加了２３．８％，心肌局部ＡＴⅡ和ＭＡＰＫ活性分别增加了４８．７６％和４４５．４％，二者显著相关，相关系数ｒ＝０．７８７，提示心肌局部ＡＴⅡ通过激活ＭＡＰＫ参与运动性心肌肥大的发生。
In long-term swimming training in rat myocardial tissue, the relationship between mitochondrial response to cardiac hypertrophy (MAPII) and MAPK (mitogen-activated protein kinase) activity was examined in order to investigate the role of AT II in promoting myocardial hypertrophy Delivery mechanism. The results showed that the heart coefficient of exercise group increased by 23.8%, and the activity of AT Ⅱ and MAPK in myocardium increased by 48.76% and 445.4% respectively, the correlation between them was significant (r = 0.787) Activation of MAPK involved in the occurrence of exercise-induced cardiac hypertrophy.