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目的 :探讨肠易激综合征 (IBS)患者血浆及乙状结肠粘膜中血管活性肠肽 (VIP)、生长抑素 (SS)有无变化 ,以及它们在IBS发病过程中的可能作用和临床意义。方法 :应用放射免疫分析法 (RIA)测定IBS患者血浆及乙状结肠粘膜内VIP、SS的含量 ,并与正常组比较。结果 :便秘型IBS血浆及乙状结肠粘膜中VIP含量显著高于正常组 (P <0 .0 1 ) ,腹泻型显著低于正常组 (P <0 .0 5) ;SS在IBS各组均显著高于正常组 (P <0 .0 5) ,而便秘型又显著高于腹泻型 (P <0 .0 5)。结论 :IBS患者存在VIP、SS含量异常 ,且这些异常可能在IBS发病中起一定的作用 ;不同类型IBS患者VIP及SS含量有显著差异 ,说明不同类型IBS在发病机制上有其不同的病理生理学基础
Objective: To investigate the changes of vasoactive intestinal peptide (VIP) and somatostatin (SS) in plasma and sigmoid mucosa of patients with irritable bowel syndrome (IBS) and their possible roles and clinical significance in the pathogenesis of IBS. Methods: The contents of VIP and SS in plasma and sigmoid mucosa of patients with IBS were measured by radioimmunoassay (RIA), and compared with the normal group. Results: The content of VIP in constipation-type IBS plasma and sigmoid mucosa was significantly higher than that in normal group (P <0.01), diarrhea was significantly lower than that in normal group (P <0.05), SS was significantly higher in IBS In the normal group (P <0.05), the constipation was significantly higher than that of the diarrhea (P <0.05). Conclusions: There are abnormalities of VIP and SS in patients with IBS, and these abnormalities may play a role in the pathogenesis of IBS. VIP and SS in different types of IBS patients are significantly different, indicating that different types of IBS pathogenesis has its different pathophysiology basis