2型糖尿病及合并高血压者胰岛素抵抗与脂蛋白(a)的研究

• 作 者: 陈小奇 范幼筠
• 机 构: 武汉大学中南医院内分泌科,武汉大学中南医院内分泌科,武汉大学中南医院内分泌科,武汉大学中南医院内分泌科 430071,430071,430071,430071
• 出 处: 辽宁实用糖尿病杂志
• 发表日期: 2002年02期
• 关键词: 胰岛素抵抗 高血压者 原发性高血压 正常血压 心脑血管病变 大血管并发症 糖耐量异常 脂代谢紊乱 高胰岛素血症 性别组成

分别测定 2型糖尿病 (A组 )、2型糖尿病合并高血压 (B组 )、原发性高血压 (C组 )及正常人 (D组 )的Lp(a)浓度。对每位利用Homa -model公式计算IRI。结果 :①A组、B组及C组的Lp(a)浓度无显著差异 ,但均显著高于D组 ;②A组与B组IRI无显著差异 ,两组均高于C组 ;③Lp(a)与A组、C组IRI无显著相关 ;与B组IRI呈显著正相关。结论 :2型糖尿病者及合并高血压者IRI无显著差异 ,Lp(a)与 2型糖尿病合并高血压者IRI呈显著正相关。

The concentrations of Lp (a) in type 2 diabetes mellitus (group A), type 2 diabetic patients with hypertension (group B), essential hypertension (group C) and normal subjects (group D) were determined. Calculate the IRI for each using the Homa-model formula. Results: ① There was no significant difference in Lp (a) concentrations between groups A, B and C, but both of them were significantly higher than those of group D. ② There was no significant difference between groups A and B, There was no significant correlation with IRI of group A and group C, but significant positive correlation with IRI of group B. CONCLUSION: There is no significant difference in IRI between type 2 diabetic patients and those with type 2 diabetes mellitus. There is a significant positive correlation between Lp (a) and IRI in type 2 diabetic patients with hypertension.