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目的：研究１７β雌二醇对氧化型低密度脂蛋白及其主要成分溶血磷脂酰胆碱（ＬＰＣ）损伤的内皮功能的保护作用．方法：在兔离体主动脉环用苯福林收缩血管后，观察氧化型ＬＤＬ及ＬＰＣ对血管舒张功能的作用．结果：１７β雌二醇显著减轻氧化型ＬＤＬ及ＬＰＣ对内皮舒张功能的损伤，并呈剂量依赖性．但吲哚美辛可拮抗１７β雌二醇的这种保护作用．结论：１７β雌二醇对氧化型ＬＤＬ或ＬＰＣ损伤的内皮功能具保护作用，其作用可能与刺激依前列醇的产生有关．
Objective: To study the protective effect of 17β-estradiol on the endothelial function of oxidized low-density lipoprotein and lysophosphatidylcholine (LPC), the main component of oxidative low density lipoprotein. Methods: The effect of oxidized LDL and LPC on vasodilatation was observed after the isolated aorta rings of rabbits were contracted with phenylephrine. Results: 17β-estradiol significantly reduced oxidative LDL and LPC on endothelial dysfunction, and in a dose-dependent manner. However, indomethacin can antagonize this protective effect of 17β-estradiol. CONCLUSION: 17β-estradiol has a protective effect on endothelial dysfunction induced by oxidative LDL or LPC, and its effect may be related to the stimulation of epoprostenol.