论文部分内容阅读
Low density lipoprotein receptor (LDL|R) plays an important role in removing LDL from plasma and preventing producing atherosclerosis. To test hepatic reconstitution of LDL|R expression is sufficient for metabolic correction of subjects with hypercholesterolemia; a recombinant adeno|associated virus (rAAV) carrying the human LDL receptor cDNA (AAV/LDL|R) was constructed. Using adenosome, a complex of adenoviral capsid protein and liposome, to transfer the rAAV into livers of rabbits with experimental hypercholesterolemia could elicit the production of LDL|R and lower plasma cholesterol level. These results demonstrate that AAV|mediated transfer of LDL|R gene may provide an alternative means to gene therapy of hypercholesterolemia.
Low density lipoprotein receptor (LDL | R) plays an important role in removing LDL from plasma and preventing productive atherosclerosis. To test hepatic reconstitution of LDL | R expression is sufficient for metabolic correction of subjects with hypercholesterolemia; a recombinant adeno Using adenosome, a complex of adenoviral capsid protein and liposome, to transfer the rAAV into livers of rabbits with experimental hypercholesterolemia could elicit (rAAV) carrying the human LDL receptor cDNA (AAV / LDL | R) was constructed. the production of LDL | R and lower plasma cholesterol level. These results demonstrate that AAV | | mediated transfer of LDL | R gene may provide an alternative means to gene therapy of hypercholesterolemia.