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目的 探讨血管内皮生长因子 (VEGF)在大肠癌组织中的表达及其与大肠癌发展的关系。方法 应用免疫组织化学LSAB法检测 5 2例人大肠癌组织的VEGF表达 ,分析VEGF与大肠癌组织学类型、分化程度、Dukes分期及淋巴结转移的关系。结果 VEGF表达率随大肠癌Dukes分期的进展而增加 ,且DukesC期的VEGF表达率与DukesA期相比有显著性差异 (P <0 .0 5 ) ;VEGF在有淋巴结转移组的表达率为 6 8.18% ,显著高于无淋巴结转移组的 40 .0 0 % (P <0 .0 5 ) ;VEGF表达与组织学类型和分化程度无关 (P >0 .0 5 )。结论 VEGF表达对大肠癌的进展有促进作用 ,VEGF可作为反映大肠癌生物学行为的指标之一
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in colorectal carcinoma and its relationship with the development of colorectal carcinoma. Methods The expression of VEGF in 52 human colorectal cancer tissues was detected by immunohistochemistry LSAB method. The relationship between VEGF and the histological type, differentiation, Dukes stage and lymph node metastasis of colorectal cancer was analyzed. Results The expression of VEGF increased with the progression of Dukes staging in colorectal cancer, and the expression of VEGF in Dukes C stage was significantly different from that in Dukes A stage (P <0.05). The expression of VEGF in the group with lymph node metastasis was 6 8.18%, which was significantly higher than 40.0% of those without lymph node metastasis (P <0.05). There was no correlation between VEGF expression and histological type and differentiation (P> 0.05). Conclusion The expression of VEGF may promote the progress of colorectal cancer, and VEGF may be one of the indicators reflecting the biological behavior of colorectal cancer