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目的:探讨p53、PCNA和EGFR在食管鳞癌中的表达情况与化疗疗效的关系。方法:对66例食管鳞癌化疗前的活检标本用免疫组化技术分别检测p53、PCNA、EGFR的表达。结果:p53蛋白积聚阳性组化疗有效率(16.7%)明显低于p53蛋白积聚阴性组(70.8%)(P<0.01),PCNA过表达组化疗有效率(79.4%)高于PCNA弱表达组(31.3%)(P<0.01),EGFR过表达组化疗有效率(30.4%)低于弱表达组(69.8%)(P<0.01)。经Logistic回归分析,3个指标中,PCNA对化疗疗效的预测价值较大(P<0.01)。结论:食管鳞癌中p53、PCNA和EGFR的表达情况对化疗疗效均有一定的预测价值。其中PCNA价值较大。
Objective: To investigate the relationship between the expression of p53, PCNA and EGFR in esophageal squamous cell carcinoma and the effect of chemotherapy. Methods: The biopsy specimens of 66 esophageal squamous cell carcinomas before chemotherapy were detected by immunohistochemistry to detect the expression of p53, PCNA and EGFR. Results: The effective rate of chemotherapy in positive group (16.7%) was significantly lower than that in negative group (70.8%) (P <0.01). The effective rate of chemotherapy in PCNA overexpression group (79.4%) was higher than that in PCNA weak group 31.3%) (P <0.01). The effective rate of chemotherapy in EGFR overexpression group (30.4%) was lower than that in weak expression group (69.8%) (P <0.01). Logistic regression analysis showed that the predictive value of PCNA for chemotherapy was higher in the three indicators (P <0.01). Conclusion: The expression of p53, PCNA and EGFR in esophageal squamous cell carcinoma have certain predictive value for the curative effect of chemotherapy. Among them PCNA value is bigger.