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对２８例非霍奇金淋巴瘤（ＮＨＬ）发生中枢神经系统合并症的（ＣＮＳＣ）发生因素进行了分析探讨。ＣＮＳＣ发生中位时间４个月，多发生在进展期。ＣＮＳＣ以颅神经症状、颅内高压征和脑膜刺激征多见。结外器官以骨髓受累最多。主要致死原因是淋巴瘤进展及转移并发症。中位生存时间３５～４个月。儿童ＣＮＳＣ发生率和死亡率比成人高，且以淋巴母细胞发生ＣＮＳＣ危险性最大。晚期病例及伴结外器官受累者易发生ＣＮＳＣ。在诸多预后因素中全身淋巴瘤状况、结外病变数是重要的预后因素。ＣＮＳＣ者应行脑照射加鞘注，尤其对淋巴母细胞Ｂｕｒｋｉｔ’ｓ、弥漫型大细胞、未分化型ＮＨＬ要在每疗程第１４天行中枢神经系统预防鞘注
The occurrence of central nervous system complications (CNSC) in 28 cases of non-Hodgkin’s lymphoma (NHL) was analyzed. The median time of occurrence of CNSC was 4 months, which mostly occurred in the advanced stage. CNSC is more common with cranial nerve symptoms, intracranial hypertension, and meningeal irritation. Extranodal organs are most involved in the bone marrow. The main cause of death was lymphoma progression and metastatic complications. The median survival time was 3 5 to 4 months. The incidence and mortality of CNS in children are higher than in adults, and the risk of CNS in lymphoblasts is greatest. Patients with advanced stage and involvement of extranodal organs are prone to CNS. In many prognostic factors, the condition of total lymphoma and the number of extranodal lesions are important prognostic factors. Patients with CNSC should be treated with brain irradiation plus sheath injection, especially for Burkit’s lymphoblasts, diffuse large cells, undifferentiated NHL, and central nervous system prevention sheath injections on the 14th day of each course of treatment.