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目的观察抗病毒清热口服液联合炎琥宁注射液治疗手足口病的临床疗效。方法将我院2013年1月至2015年10月儿科217例感染柯萨奇A16型等病毒患者随机分为治疗组和对照组,对照组107例每日给予炎琥宁注射液(5~10 mg·kg~(-1),加入5%葡萄糖注射液100~250 mL)静脉滴注治疗;治疗组110例在对照组治疗基础上再给予抗病毒清热口服液治疗。观察两组患儿治疗后的疗效、退热时间、疱疹和皮疹开始消退时间及住院时间等情况。结果治疗组患儿的平均痊愈时间(5.4 d)显著低于对照组(7.7 d),治疗组患儿的退热时间、口腔疱疹开始消退时间和皮疹开始消退时间也显著低于对照组,差异有统计学意义(P<0.05);治疗组的痊愈率(84.5%)显著高于对照组的痊愈率(55.1%),两组疗效的有效率分别为96.4%和90.7%,差异均有统计学意义(P<0.05)。结论抗病毒清热口服液联合炎琥宁治疗儿童手足口病临床效果显著,能提高患儿痊愈率并缩短治疗时间及住院时间。
Objective To observe the curative effect of antivirus Qingre oral liquid combined with Yanhuoning injection in the treatment of hand, foot and mouth disease. Methods A total of 217 patients infected with Coxsackie A16 virus in pediatric department from January 2013 to October 2015 were randomly divided into treatment group and control group. In the control group, 107 cases were given Yanhuoning Injection (5-10 mg · kg ~ (-1), adding 5% dextrose injection 100 ~ 250 mL) intravenously. The treatment group (110 cases) was treated with anti-virus Qingre oral liquid on the basis of the control group. The curative effect, withdrawal time, herpes and rash began to subside and the length of stay in both groups were observed. Results The mean recovery time (5.4 days) in the treatment group was significantly lower than that in the control group (7.7 days). The antipyretic time, the onset time of onset of herpes simplex and the subsidence of the rash in the treatment group were also significantly lower than those in the control group (84.5%) in the treatment group was significantly higher than that of the control group (55.1%), the effective rates of the two groups were 96.4% and 90.7%, respectively, with statistical differences Significance (P <0.05). Conclusion Antiviral Qingre Oral Liquid combined with Yan Hu Ning hand-foot-mouth disease in children with significant clinical effect, can improve the cure rate and shorten the treatment time and hospital stay.