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为探讨雾化吸入布地奈德对鼻咽癌调强放疗致鼻口等相关并发症的防治作用,用随机数字法将行调强放疗治疗的80例鼻咽癌患者分为观察组与对照组,各40例,观察组放疗期间给予布地奈德雾化吸入干预,对照组常规生理盐水干预,比较两组放疗前后气导听阈变化、放疗后鼻咽粘膜反应程度、不同放射剂量III度黏膜损伤情况及相关并发症发生率。观察组放疗结束后语言频区平均气导听阈值显著低于对照组(p<0.05);观察组放疗结束后鼻咽黏膜反应程度显著轻于对照组(p<0.05);观察组放疗剂量31~50 Gy、51~70 Gy时3度黏膜损伤发生率均显著低于对照组(p<0.05);观察组中耳炎、副鼻窦炎、鼻腔粘连、后鼻孔狭窄及咽喉干燥感发生率分别为27.50%、57.50%、15.00%、10.00%、22.50%,均显著低于对照组的50.00%、87.50%、37.50%、30.00%、75.00%,差异有统计学意义(p<0.05)。鼻咽癌调强放疗治疗期间给予布地奈德雾化吸入干预能明显减轻患者鼻咽黏膜损伤程度,有效减少鼻咽口相关并发症发生。
In order to investigate the preventive and therapeutic effects of inhaled budesonide on the nasal passages and other complications associated with intensity modulated radiotherapy of nasopharyngeal carcinoma, 80 nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy were randomly divided into observation group and control group , 40 cases in each group. During the radiotherapy, budesonide inhalation was given to the observation group. The control group received conventional saline intervention. The changes of air conduction threshold before and after radiotherapy were compared between the two groups. The degree of nasopharyngeal mucosa reaction, Situation and related complication rates. After the end of radiotherapy, the mean value of air conduction hearing threshold was significantly lower in the observation group than in the control group (p <0.05); the response of nasopharyngeal mucosa in the observation group was significantly lower than that in the control group (p <0.05) The incidence of 3 degree mucosal lesion in ~ 50 Gy and 51 ~ 70 Gy group was significantly lower than that in control group (p <0.05). The incidences of otitis media, sinusitis, nasal adhesions, posterior nasal cavity stenosis and throat soreness in the observation group were 27.50 %, 57.50%, 15.00%, 10.00% and 22.50%, respectively, were significantly lower than those in the control group (50.00%, 87.50%, 37.50%, 30.00% and 75.00%, respectively). During the treatment of nasopharyngeal carcinoma with intensity modulated radiotherapy, the intervention of inhalation of budesonide inhalation can significantly reduce the degree of nasopharyngeal mucosa injury and effectively reduce the incidence of nasopharyngeal related complications.