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作者综述了一氧化氮(NO)在利什曼病和疟疾两种重要的寄生虫病中的作用。1)NO的抗寄生虫活性:在微量脂多糖(LPS)存在下,经IL-1,IFN-γ,TNF-α和移动抑制因子等的刺激,鼠巨噬细胞表达出高水平的NO合成酶并产生大量的NO。与培养基中单独培养的对照细胞相比,这些被激活的巨噬细胞可以高度有效地杀死细胞内和细胞外的寄生虫。2)NO的病理效应:一些实验模型显示,过量产生的NO会导致一些病理结果和严重的免疫病症如糖尿病、移植后的宿主反应疾病、实验性变应性脑脊髓炎、肝硬化、
The authors review the role of nitric oxide (NO) in two important parasitic diseases, leishmaniasis and malaria. 1) Anti-parasite activity of NO: Murine macrophages expressed high levels of NO synthesis by the stimulation of IL-1, IFN-γ, TNF-α and migration inhibitory factors in the presence of micro-lipopolysaccharide (LPS) Enzyme and produce large amounts of NO. These activated macrophages can kill both intracellular and extracellular parasites highly efficiently compared to control cells cultured alone in culture. 2) Pathological Effects of NO: Some experimental models have shown that excessive NO production leads to some pathological findings and severe immune disorders such as diabetes, post-transplant host reaction diseases, experimental allergic encephalomyelitis, cirrhosis,