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检测子宫内膜癌组织中雌激素受体 (ER)、孕激素受体 (PR)及 P5 3表达的阳性率并探讨其临床意义。方法 :用免疫组化法对 33例子宫内膜癌标本进行了 ER、 PR及 P5 3 的检测。结果 :子宫内膜癌组织中 ER、 PR及 P5 3 的总阳性率分别为6 6 .5 7%、 6 3.6 4%、 2 7.2 7% ,ER、PR、P5 3阳性表达率与癌组织的细胞分化程度有关 ,随着子宫内膜癌组织学分级的增高 ,ER、 PR阳性表达率逐渐降低 ,而 P5 3 的阳性率逐渐升高 (P <0 .0 5 )。与临床分期关系无统计学意义。结论 :ER、 PR、 P5 3 及组织学分级均反映了子宫内膜癌的生物学行为 ,它们的测定对估计患者预后和临床选择内分泌治疗具有重要意义。
The positive rate of estrogen receptor (ER), progesterone receptor (PR) and P53 expression in endometrial cancer tissues was examined and its clinical significance was explored. Methods : ER, PR and P53 were detected in 33 specimens of endometrial carcinoma by immunohistochemistry. Results: The total positive rates of ER, PR and P53 in endometrial cancer tissues were 66.57%, 63.64%, and 27.27% respectively. The positive expression rates of ER, PR, and P53 were associated with cancer tissues. The degree of cell differentiation was related to the increase in the histological grade of endometrial cancer, the positive expression rate of ER and PR was gradually decreased, while the positive rate of P53 was gradually increased (P < 0.05). There was no statistically significant relationship with clinical stage. Conclusion: The ER, PR, P53 and histological grade all reflect the biological behavior of endometrial carcinoma. Their determination is of great significance in estimating the prognosis of patients and clinical selection of endocrine therapy.