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[目的]了解上海市虹口区普查妇女中高危型人乳头瘤病毒(HPV)的感染情况,并探讨其在宫颈癌前病变中的作用。[方法]对318例普查妇女行高危型HPV-DNA检测及病理检测。[结果]病理检查阴性者HPV感染率为10.8%(21/195),低度子宫颈病变者HPV感染率为25.0%(4/16),高度子宫颈病变者HPV感染率为81.8%(9/11)。HPV诊断宫颈癌前病变的灵敏度为48.1%,特异度为89.2%,阳性预测值为38.2%,阴性预测值为92.6%。[结论]HPV感染是宫颈癌及癌前病变的高危因素。HPV-DNA检测具有较高的阴性预测值,在宫颈癌筛查中具有重要作用。
[Objective] To investigate the prevalence of high-risk human papillomavirus (HPV) among census women in Hongkou district, Shanghai and to explore its role in precancerous lesions of the cervix. [Methods] The 318 pregnant women underwent high-risk HPV-DNA detection and pathological examination. [Results] The positive rate of HPV infection was 10.8% (21/195) in pathological examination negative, HPV infection rate was 25.0% (4/16) in low cervix disease, and HPV infection rate in high cervix disease was 81.8% (9 / 11). The sensitivity of HPV in diagnosing cervical precancerous lesions was 48.1%, the specificity was 89.2%, the positive predictive value was 38.2% and the negative predictive value was 92.6%. [Conclusion] HPV infection is a high risk factor for cervical cancer and precancerous lesions. HPV-DNA test has a high negative predictive value in cervical cancer screening plays an important role.