论文部分内容阅读
目的:探讨肺转移瘤外科治疗的指征、术前评价、手术方法及影响预后的因素。方法:对106 例肺转移瘤的临床资料进行回顾性分析。结果:经手术治疗的肺转移瘤106 例,其中转移性癌86 例,转移性肉瘤20 例,二者5 年生存率分别为19 .8% 和20% 。以原发肿瘤乳腺癌、头颈部癌、泌尿系癌及骨肉瘤的肺转移预后较好,5 年生存率分别为33 .3 % 、27 .3 % 、20 % 及33 .3 % 。全组1 年、3 年、5 年和10 年生存率分别为83 % 、35 .8 % 、9.8 % 和6 .6 % 。术后行跟放/ 化疗者的5 年生存率为18 .1 % ,未行者23 .5 % ,二者间差异不显著。全组并发症的发生率为4.2 % ,无手术死亡。结论:对原发肿瘤已达根治,无他处转移及肺功能可承受手术者作为手术指征;手术途径以病侧后外切口为主;探查时应避免遗漏多发转移灶,遵循最大限度切除肺转移瘤及保留正常肺组织的原则;重视前瞻性的术后辅助治疗,以期提高手术疗效。
Objective: To investigate the indications for surgical treatment of pulmonary metastases, preoperative evaluation, surgical methods, and factors influencing prognosis. Methods: The clinical data of 106 cases of lung metastases were retrospectively analyzed. Results: Of the 106 lung metastatic tumors treated with surgery, 86 were metastatic carcinomas and 20 were metastatic sarcomas. The 5-year survival rate was 19%. 8% and 20%. The prognosis of lung metastases with primary tumors of breast, head and neck, urinary tract, and osteosarcoma was better, with a 5-year survival rate of 33%. 3%, 27 . 3%, 20% and 33. 3%. The 1-, 3-, 5-, and 10-year survival rates for the whole group were 83% and 35, respectively. 8 %, 9.8%, and 6. 6 %. The 5-year survival rate of patients who underwent postoperative radiotherapy and chemotherapy was 18%. 1 %, not 23. 5 %, the difference between the two is not significant. The incidence of complications in the whole group was 4.2%, and no operative death occurred. Conclusion: The primary tumor has reached a radical treatment, no other metastasis and pulmonary function can withstand the operation as an indication for surgery; surgical approach to the disease side of the main external incision; exploration should avoid multiple missed metastases, follow the maximum removal Pulmonary metastases and retention of normal lung tissue principles; emphasis on prospective postoperative adjuvant therapy in order to improve the efficacy of surgery.