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3-氯丙二醇(3-chloro-1、2-propane-diol,别名α-氯代甘油,α-chlorohydrin,缩写α-ch),系主要作用于附睾及其内精子的抗生育药物,能引起多种雄性动物如大白鼠、豚鼠、猴等的不育。该药物的抗生育作用,与抑制精子发生类药物相比,有起效怏、不妨碍性功能和停药后生育力恢复较快的优点。但由于它的有效安全范围较窄,在高剂量使用时易引起大白鼠附睾管阻塞及猴的骨髓抑制,因此,目前尚不能作为避孕药物在临床运用。
3-chloro-1, 2-propane-diol (alias α-chlorohydrin, abbreviated α-ch) is an antifertility drug that mainly acts on the epididymis and its internal sperm and can cause A variety of male animals such as rats, guinea pigs, monkeys and other infertility. The anti-fertility effect of the drug has the advantages of being effective, preventing sexual function, and recovering fertility after stopping drug, compared with the drugs that inhibit sperm production. However, due to its narrow range of effective safety, it is easy to cause obstruction of the epididymal duct in rats and inhibition of bone marrow in monkeys when used at high doses. Therefore, it is not yet available as a contraceptive drug in clinical practice.