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Objective:To compare the effect between nebulized and intravenous administration of Shenmai Injection(参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-reperfusion.Methods:Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method:Shenmai Injection was administered 30 min before tourniquet inflation by nebulization[0.6 mL/kg in 10 mL normal saline(NS)]in the nebulization group or by intravenous drip(0.6 mL/kg dissolved in 250 mL of 10%glucose) in the intravenous drip group,and equal volume of NS was given intravenously in the NS group;15 in each group.Arterial blood gases were analyzed,serum levels of malonaldehyde(MDA) and interleukine-6(IL-6) and interleukine-8(IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflation(TO),and at 0.5 h(T1),2 h(T2),6 h(T3) after tourniquet deflation.Results:Compared with baselines at TO,MDA levels significantly increased at T2,T3 in the NS group and at T3 in the nebulization group,and IL-6 and IL-8 levels were significantly increased at T2,T3 in NS,the intravenous drip and the nebulization groups(P<0.05).Arterial pressure of oxygen(PaO_2) at T3 was decreased,while alveolararterial oxygen tension showed difference(PA-aDO_2) at T3 in the NS group;RI at T3 in both intravenous drip and the nebulization groups were enhanced(P<0.05).Compared with the NS group,MDA and IL-8levels at T2,T3,IL-6 at T3 in the intravenous drip group,and IL-8 at T3 in the nebulization group were all remarkably increased(P<0.05).Additionally,MDA level at T3 in the nebulization group was higher than that in the intravenous drip group(P<0.05).Conclusions:Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-reperfusion.
Objective: To compare the effect between nebulized and intravenous administration of Shenmai Injection on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-reperfusion. Methods: Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method: Shenmai Injection was administered 30 min before tourniquet inflation by nebulization [0.6 mL / kg in 10 mL normal saline (NS)] in the nebulization group or by intravenous drip (0.6 mL / kg dissolved in 250 mL of 10% glucose in the intravenous drip group, and equal volume of NS was given intravenously in the NS group; 15 in each group. Arterial blood gases were analyzed, serum levels of malonaldehyde (MDA) and interleukine- 6) and interleukine-8 (IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflation (TO), and at 0.5 h (T1), 2 h 6 h (T3) after tourniquet deflation. Results: Compared with baselines at TO, MDA levels significantly increased at T2, T3 in the NS group and at T3 in the nebulization group, and IL-6 and IL-8 levels were significantly increased at T2, T3 in NS, The intravenous drip and the nebulization groups (P <0.05). Arterial pressure of oxygen (PaO_2) at T3 was decreased, while alveolaraerial oxygen tension showed difference (PA-aDO_2) at T3 in the NS group; RI at T3 in both intravenous drip and the nebulization groups were enhanced (P <0.05) .Compared with the NS group, MDA and IL-8levels at T2, T3, IL-6 at T3 in the intravenous drip group, and IL-8 at T3 in the nebulization group were Additionally, MDA level at T3 in the nebulization group was higher than that in the intravenous drip group (P <0.05). Conclusions: Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induce d limb ischemia-reperfusion.