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目的：探讨脂肪乳治疗氯氮平中毒治疗干预措施的临床效价比。方法回顾性分析17例氯氮平中毒病例资料，比较血液净化治疗组（10例）与脂肪乳治疗组（7例）血药浓度清除率，住院时间、医疗花费、住院期间日均治疗干预评分（TISS-28）之间的差异。结果脂肪乳治疗的氯氮平清除率（31.8%～34.3%/次）与血浆置换（29.2%～31.6%/次）接近，显著高于血液透析（12.7%～16.6%）和血液灌流（19.9%～21.4%）。脂肪乳组患者住院时间明显短于血液净化组（11.7±8.3d VS 19.9±18.4d,P=0.004），医疗花费（26813.45±17462.88元VS 7498.33±4166.51元,P=0.000）及日均TISS-28评分（41.2±20.3分VS 28.1±11.4分，P=0.008）均低于于血液净化组，差异均有统计学意义（P<0.01）。结论脂肪乳对氯氮平中毒的疗效与血浆置换相近，优于血液灌流或透析；可显著减少治疗干预措施，临床效价比较好，值得进一步深入研究。“,”Objective:To explore the clinicpotency ratioof treating intervention on clozapine poisoning treated with lipid infusion. Methods:Data of 17 patients with clozapine poisoning were analyzedretrospectively. Theblood concentrationof clozapine,long of stay,medical costand average TISS -28 per day were compared betweenhemopurificationgroup (10 cases)and lipid infusion group (7cases)respectively. Results:The clearance rate ofblood concentrationof clozapine in lipid infusion treatment group(31.8%~34.3%per one time)was closed to that ofplasmapheresisgroup(29.2%~31.6%per one time);exceeded to that of inhemoperfusion(19.9%~21.4%per one time)and hemodialysis (12.7%~16.6%per one time)significantly. The long of stay in lipid infusion treatment group (11.7 ±8.3d)was significantly shorter than that of inhemopurificationgroup(19.9±18.4d),P=0.004;but al ofmedical cost(26813.45±17462.88yuanVS 7498.33±4166.51yuan, P=0.000)and TISS-28(41.2±20.3VS 28.1±11.4,P=0.008)were inferior to that of inhemopurificationgroup. Conclusion:Thecurative ef ectof clozapine poisoning treated with lipid infusion isclose tothat ofplasmapheresis,and superior to that ofhemoperfusionand hemodialysis.The treatment of lipid infusion maybe can decrease the treating interventions and has bet er clinic potency ratio than that ofhemopurification.