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最近,几个报告都指出,在大鼠和兔,黄体生成素释放激素(LH-RH)和它的几种类似物具有很强的交配后避孕活性。作者最近发现,用第6位D构型亮氨酸,第10位去甘氨酸的LH-RH的乙基酰胺处理,导致睾丸黄体生成素/人绒毛膜促性腺激素(LH/HCG)受体的明显减少和血浆睾丸酮水平的明显降低。这使作者想到,LH-RH类似物的交配后抗生育作用可能是通过内源性LH引起的卵巢失敏感来中解的。这篇报告描述用第6位D
Recently, several reports have pointed out that in rats and rabbits, luteinizing hormone-releasing hormone (LH-RH) and several of its analogues have strong post-mating contraceptive activity. The authors have recently found that treatment with LH-RH ethylamide at D-6, D-form, position 10, to glycine results in a decrease in testis luteinizing hormone / human chorionic gonadotropin (LH / HCG) Significantly reduced and plasma testosterone levels were significantly reduced. This led the authors to think that the post-mating anti-fertility effects of LH-RH analogs might be mediated by the ovarian desensitization induced by endogenous LH. This report uses the first six D