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目的观察肺上皮样血管周细胞瘤(neoplasms with perivascular epithelioid cell,PEComa)的临床病理特点。方法对本院2008年会诊的1例肺PEComa进行临床病理资料分析和光镜、免疫组化标记观察并复习相关文献。结果肺PEComa临床表现与其他肺肿瘤比较无独特性。其是起源于血管周细胞的良性间叶性肿瘤,镜检瘤细胞呈圆形、卵圆形,富含糖原,细胞核无明显异型,未见核分裂像及瘤性坏死。免疫组化标记该肿瘤细胞特异性表达黑色素标记HMB-45及S-100。结论 PEComa发生于肺比较罕见,与肺的其他恶性肿瘤鉴别需借助病理及免疫组化标记。
Objective To observe the clinicopathological features of neoplasms with perivascular epithelioid cell (PEComa). Methods One case of pulmonary PEComa consultation in 2008 in our hospital was analyzed by clinicopathological data and light microscope, immunohistochemical markers and review of relevant literature. Results The clinical manifestations of pulmonary PEComa were not distinct from those of other lung tumors. It is a benign mesenchymal tumor that originates from perivascular cells. The tumor cells are round, oval and rich in glycogen. There is no obvious abnormality in the nucleus. There are no mitoses and tumor necrosis. Immunohistochemical labeling of the tumor cells specifically expressed melanin-labeled HMB-45 and S-100. Conclusions PEComa occurs relatively rarely in the lungs and is differentiated from other malignant tumors of the lung by pathology and immunohistochemistry.