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环孢霉素Ａ（ＣｓＡ）肾毒性的作用机理至今不十分明确，而反应性氧代谢产物（ＲＯＭ）与许多肾脏疾病有关。将Ｗｉｓｔａｒ大鼠分别给ＣｓＡ三种剂量１２．５、２５、５０ｍｇ·ｋｇ－１／ｄ日灌胃７天，大鼠出现急性肾功能不全，血肌酥、血清及肾皮质匀浆丙二醛显著升高，而肾皮质匀浆超氧化物歧化酶活性及全血谷胱甘肽过氧化物酶活性下降。在人参总皂甙及去铁敏预防组中，上述指标与正常组无显著差异，提示ＲＯＭ产生的增加及肾脏抗氧化能力的下降参与了ＣｓＡ所致的急性肾毒性，而入参总皂甙、去铁敏具有预防作用。
The mechanism of action of cyclosporin A (CsA) nephrotoxicity is not well understood to date, and reactive oxygen metabolites (ROMs) are associated with many renal diseases. Wistar rats were given CsA three doses of 12.5,25,50 mg · kg-1 / d gavage for 7 days, rats with acute renal insufficiency, serum creatinine, serum and renal cortical plasma malondialdehyde Significantly increased, while renal cortical superoxide dismutase activity and whole blood glutathione peroxidase activity decreased. In ginseng total saponin and deferoxamine prophylaxis group, the above indicators no significant difference with the normal group, suggesting that increased ROM production and renal antioxidant capacity decreased in acute renal toxicity caused by CsA, and into the ginseng saponin, go Minmin has a preventive effect.