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【据《Hepatology》2017年11月报道】题:单细胞转录组分析揭示了成肝细胞分化的精确途径和调控机制(作者Yang L等)双潜能成肝细胞如何分化为肝实质细胞和肝内胆管细胞尚不清楚。通过对从胚胎发育10.5 d(E10.5)至E17.5的小鼠胚胎中分选得到的成肝细胞、肝实质细胞和肝内胆管细胞进行单细胞转录组分析,发现成肝细胞向肝实质细胞的分化是逐渐发生的,遵循线性的细胞命运“默认”的途径。并且,随着更多的细胞转变为完全分
According to Hepatology, November 2017 report Title: Single Cell Transcriptome Analysis Reveals Precise Pathways and Regulatory Mechanisms of Hepatocyte Differentiation (by Yang L et al.) How Dual-Capable Hepatocytes Differentiate into Hepatic Parenchymal Cells and Hepatic Cholangiocytes are not yet known. Single-cell transcriptome analysis of hepatoblasts, hepatic parenchymal cells and intrahepatic cholangiocytes sorted from mouse embryos of embryonic development 10.5 d (E10.5) to E17.5 revealed that hepatoblasts to the liver Parenchymal cell differentiation occurs gradually, following the path of linear cell fate “default ”. And, as more cells turn into perfect points