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目的通过Nogo事件相关电位检测,对Nogo事件相关电位的起源及其与注意缺陷多动障碍(ADHD)患儿的执行功能进行探讨。方法对36例ADHD患儿(病例组)和30例健康儿童(健康对照组)进行Nogo事件相关电位检测,检测中受试者需对稀有声刺激执行按键反应(代表Go反应),对标准声刺激不执行按键反应(代表Nogo反应),从Nogo反应中可获得Nogo-P300电位,其主成分Nogo-N2、Nogo-P3即出现于Nogo事件相关电位中。对Nogo-N2、Nogo-P3的波幅进行测量。结果病例组Nogo-N2波幅负性程度低于健康对照组[-(5.36±1.87)μVvs-(7.85±1.74)μV],Nogo-P3波幅亦低于健康对照组[(5.62±2.36)μVvs(8.32±2.03)μV],2组比较差异均有统计学意义(t=4.92、5.55,Pa<0.01)。结论 Nogo-N2、Nogo-P3波幅降低,说明ADHD患儿抑制性执行功能不足,其电生理学指标Nogo-N2波幅降低,可反映其前扣带回功能异常;Nogo-P3波幅负性程度降低,可反映其前额叶、前扣带回脑区功能异常。通过Nogo事件相关电位检测,可为ADHD患儿的诊断提供客观依据。
Objective To investigate the origin of Nogo-related potential and its executive function in children with attention deficit hyperactivity disorder (ADHD) through Nogo event-related potential test. Methods Totally 36 children with ADHD (case group) and 30 healthy children (healthy control group) were subjected to Nogo event-related potential test. Subjects under test were required to perform key reaction to rare acoustic stimulation (representing Go reaction) Nogo-P300 potentials were obtained from the Nogo reaction without stimulation of the key reaction (representing the Nogo reaction). The major components of Nogo-N2 and Nogo-P3 appeared in the Nogo event-related potentials. The amplitude of Nogo-N2, Nogo-P3 was measured. Results The negative amplitude of Nogo-N2 in patients was lower than that in healthy controls [- (5.36 ± 1.87) μVvs- (7.85 ± 1.74) μV], and the amplitude of Nogo-P3 was also lower than that of healthy controls [(5.62 ± 2.36) μVvs 8.32 ± 2.03) μV]. There were significant differences between the two groups (t = 4.92,5.55, Pa <0.01). Conclusion Nogo-N2, Nogo-P3 amplitude decreased, indicating that ADHD children with impaired executive function, the electrophysiological indicators of Nogo-N2 amplitude decreased, reflecting the anterior cingulate gyral dysfunction; negative amplitude of Nogo-P3 amplitude decreased, Can reflect the prefrontal cortex, anterior cingulate anomalies back to the brain area. Through the Nogo event-related potential detection, ADHD can provide an objective basis for the diagnosis of children.