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目的:研究高血压病患者过氧化物酶体增殖物激活受体(PPAR)γ2基因Pro12Ala多态性与血糖水平之间的关系。方法:纳入177名原发性高血压患者,其中空腹血糖(FBG)<5.6 mmol/L组65例,FBG≥5.6 mmol/L组112例,收集一般资料;分别测定空腹及餐后2小时血糖、胰岛素;对PPARγ2基因Pro12Ala多态性与各临床变量的关系进行研究。结果:FBG<5.6 mmol/L组和FBG≥5.6 mmol/L组Pro和Ala等位基因频率分别为0.333,0.034及0.602,0.031;PP和PA基因型频率分别为0.299,0.068及0.571,0.062;无AA型纯合子。以体重指数(BMI)分层后,BMI<25组内,FBG与PPARγ2基因型相关(P=0.029)。以基因型分组比较,PA组空腹血糖水平和胰岛素抵抗指数都低于PP组(P<0.05)。结论:成都地区高血压患者PPARγ2基因Pro12Ala多态性与空腹血糖水平相关,且携带Ala基因者空腹血糖水平较低,胰岛素抵抗较轻,推测该突变可能有减轻高血压病患者胰岛素抵抗,改善糖代谢异常的作用。
Objective: To study the relationship between the polymorphism of Pro12Ala in peroxisome proliferator activated receptor (PPAR) γ2 gene and blood glucose level in patients with essential hypertension. Methods: One hundred and seventy-seven patients with essential hypertension were enrolled in this study. One hundred and twenty-five patients with FBG 5.6 mmol / L and 112 patients with FBG 5.6 mmol / L were enrolled in this study. General data were collected. Fasting and postprandial blood glucose , Insulin; PPARγ2 gene Pro12Ala polymorphism and the relationship between clinical variables. Results: The allele frequencies of Pro and Ala in FBG group with 5.6 mmol / L and FBG group: 5.6 mmol / L were 0.333,0.034 and 0.602,0.031, respectively. The frequencies of PP and PA genotypes were 0.299, 0.068 and 0.571, 0.062, respectively. No AA homozygotes. After stratified by body mass index (BMI), FBG was associated with PPARγ2 genotype in BMI <25 group (P = 0.029). Compared with PP group, fasting blood glucose and insulin resistance index in PA group were significantly lower than those in PP group (P <0.05). Conclusion: The polymorphism of PPARγ2 gene Pro12Ala in hypertensive patients in Chengdu is related to fasting blood glucose level, and the fasting blood glucose level is lower and the insulin resistance is lighter in Ala patients. It is presumed that this mutation may reduce the insulin resistance and improve the blood sugar of hypertensive patients The role of metabolic abnormalities.