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目的:检测冠心病患者血清中纳米细菌感染率与高敏C反应蛋白(hs-CRP)的浓度,并探讨其临床意义。方法:采用酶联免疫吸附试验(ELISA)检测冠心病组与对照组血清中的纳米细菌抗原,同时用免疫比浊法测定其血清中的hs-CRP,并进行相关性分析。结果:冠心病组血清纳米细菌感染率为27.08%(13/48),与对照组6.25%(3/48)比较,差异有统计学意义(P<0.05)。冠心病组hs-CRP浓度(4.81±7.12)mg/L显著高于对照组(0.73±0.80)mg/L,差异有统计学意义(P<0.05)。冠心病组血清hs-CRP与纳米细菌血清检测结果呈正相关(r=0.489,P<0.05)。结论:冠心病患者血清中的纳米细菌感染率与hs-CRP浓度均升高,二者具有正相关关系。
OBJECTIVE: To detect the nosocomial infection rate and high-sensitivity C-reactive protein (hs-CRP) in serum of patients with coronary heart disease (CHD) and to investigate its clinical significance. Methods: Nanobacterial antigens were detected by enzyme-linked immunosorbent assay (ELISA) in serum of patients with coronary heart disease and control group. Serum hs-CRP was measured by immunoturbidimetry and the correlation was analyzed. Results: The infection rate of serum of patients with coronary heart disease was 27.08% (13/48), which was significantly different from that of control group (6.25%, 3/48) (P <0.05). The concentration of hs-CRP in coronary heart disease group (4.81 ± 7.12) mg / L was significantly higher than that in control group (0.73 ± 0.80) mg / L, the difference was statistically significant (P <0.05). Coronary heart disease serum hs-CRP and nano-bacterial serum test results were positively correlated (r = 0.489, P <0.05). Conclusion: The infection rate of nosocomial bacteria and the concentration of hs-CRP in serum of patients with coronary heart disease are both positive.