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1952年Rusoff等人在苄星青霉素G的药代动力学研究中观察到,肌注120万单位后一月内血浆药物浓度均达到或超过对A组链球菌的最小抑菌浓度(MIC≥0.02μg/ml)。因此提出预防风湿热复发的简单有效途径。30年后Ginsburg根据自已临床实验结果提出异议:肌注120万单位后第四周内血浆浓度低于MIC,甚至检测不到。1986年有人提出应每3周肌注一次120万单位,而不是每4周。本实验采集了不同年龄组患者193份血浆标本。这些患者均朋注120万单位苄星青霉素G。于注射后即刻、1、3、10、21与28天抽取血浆标本。其中即刻血浆12份,1天35
In 1952 Rusoff et al in the benzathine penicillin G pharmacokinetic studies were observed within 1 month after intramuscular injection of 1.2 million units of plasma drug concentrations reached or exceeded the minimum inhibitory concentration of Streptococcus group A (MIC ≥ 0.02 μg / ml). Therefore, a simple and effective way to prevent recurrence of rheumatic fever is proposed. Ginsburg, 30 years later, disagreed on the results of his own clinical trial: Plasma concentrations were below MIC in the fourth week after intramuscular injection of 1.2 million units and were undetectable. It was suggested in 1986 that 1,200,000 units should be intramuscularly administered every 3 weeks instead of every 4 weeks. In this study, 193 plasma samples from different age groups were collected. Each of these patients was peer-injected with 1.2 million units of penicillin-G. Immediately after injection, plasma samples were taken at 1, 3, 10, 21 and 28 days. Immediately 12 of which plasma, 1 day 35