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本文采用本室建立的方法平行检测了192例各类肝脏疾病及721例非肝脏疾病患者血清谷胱甘酞-S转移酶(EC2.5.1.18,GST)及GPT水平。结果表明,血清GST活性测定是一项特异性和敏感性均较好的肝功能指标,诊断急性肝损害的敏感性与GPT相似,诊断慢性肝损害的敏感性明显优于GPT;对重型肝炎的预后判断也有重要意义,“GST/GPT分离”是预后不良的标志。血清GST活性变化与肝脏的病理改变一致,动态观察血清GST活性变化可能是一项间接了解肝脏病理改变的可靠指标。此外,血清GST活性测定还有助于肝细胞性黄疸与其他性质黄疸的鉴别。
In this study, we established a parallel method to detect serum glutathione-S-transferase (EC2.5.1.18, GST) and GPT in 192 cases of various liver diseases and 721 cases of non-liver disease. The results showed that the determination of serum GST activity is a good specificity and sensitivity of liver function indicators, the sensitivity of diagnosis of acute liver injury and GPT similar to the diagnosis of chronic liver damage was significantly better than the sensitivity of GPT; severe hepatitis Prognosis is also important, “GST / GPT separation” is a sign of poor prognosis. Serum GST activity changes consistent with the pathological changes of the liver, dynamic observation of changes in serum GST activity may be an indirect indicator of liver pathological changes in a reliable indicator. In addition, serum GST activity determination also contributes to the identification of hepatocellular jaundice and other jaundice.