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采用单克隆抗体Ｌｅｕ６间接免疫酶标法对新疆车排子地区地方性慢性砷中毒（ＥＣＡ）２５例３０份皮损内郎格罕细胞（ＬＣ）进行研究，发现２５份非肿瘤性角化症病变区表皮的角质层增厚，表皮内ＬＣ数增加，３份色素异常性皮损的表皮色素颗粒减少或消失区内ＬＣ数较多。２份恶性角化症，且份为鲍温病，其病变区内ＬＣ数目较多，而另１份鳞癌的癌巢中未见ＬＣ。认为砷角化症及色素异常的发生、发展及皮肤癌变的可能与皮肤ＬＣ有着密切的关系。
In this study, 25 cases of local chronic arsenism (ECA) 25 in Lancanghans cells (LC) of lesion lesions were studied by indirect immunosorbent assay using Leu6 monoclonal antibody and found 25 non-neoplastic keratosis Lesions in the epidermis of the stratum corneum thickening, increased number of LC in the epidermis, epidermal pigment particles in 3 cases of pigmented skin lesions reduce or disappear more LC number. 2 malignant keratosis, and as Bowen’s disease, the lesion more LC number, while the other squamous cell carcinoma of the nest no LC. That arsenic keratosis and dysplasia, development and skin cancer may have a close relationship with the skin LC.