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1.实验用具有Thomas改良式小胃狗3只,其中2只单次皮下注射乙素20毫克/公斤后,对胃液分泌量没有显著影响。皮下注射40毫克/公斤连续12天,胃液分泌总量无显著变化,仅在给药的个别天数的第1小时的胃液分泌略有减少,对胃液酸度及消化力的影响也不明显。另1只狗单次皮下注射80毫克/公斤,在前后2次试验中,4小时胃液分泌总量都受到显著抑制,其中以第1、第2、第3小时减少最明显,胃液酸度(游离酸、总酸)及消化力也有明显减弱现象。 2.狗2只每天皮下注射乙素40毫克/公斤,共12天。于给药后5—20分钟出现催眠作用,催眠时间持续在80分钟左右。在给药几次以后有消减现象,以后又有回升,至第11、第12天时,动物的催眠作用再度出现减弱,有一定的耐受现象。 3.单次皮下注射乙素20及80毫克/公斤或是40毫克/公斤多次给药,对上述3只狗的呼吸都没有明显影响。
1. Experimental with Thomas modified small stomach dog 3, of which two single subcutaneous injection of 20 mg / kg of B, the secretion of gastric juice had no significant effect. Subcutaneous injection of 40 mg / kg for 12 consecutive days showed no significant change in the total amount of gastric juice secretion, only a few days in the first few days of administration of gastric juice secretion decreased slightly, the gastric juice acidity and digestion power is not obvious. The other one dog subcutaneous injection of 80 mg / kg, 2 times before and after the test, 4 hours the total amount of gastric secretion were significantly inhibited, of which 1, 2, 3 hours to reduce the most obvious, gastric acidity (free Acid, total acid) and digestibility also significantly weakened. 2 dogs 2 subcutaneous injections of B 40 mg / kg, a total of 12 days. Hypnosis occurred 5-20 minutes after administration, hypnosis duration of about 80 minutes. After administration several times to reduce the phenomenon, then picked up again, to 11, 12 days, the animal’s hypnotic effect once again weakened, there is a certain degree of tolerance. 3. A single subcutaneous injection of B 20 and 80 mg / kg or 40 mg / kg multiple administration, the three dogs had no significant respiratory effects.