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[目的]:评价清下化瘀方配合常规西药治疗对急性胰腺炎的胃肠道及免疫功能的保护作用。[方法]将65例急性胰腺炎患者分为治疗组32例、对照组33例。其中,对照组给予西药常规治疗,治疗组在西药常规治疗的基础上加服清下化瘀方。2组均治疗7d后,通过观察临床症状积分的缓解程度以及监测血淀粉酶、CRP、补体C3/C4,并给予APACHEⅡ积分评分评价其功能。[结果]治疗后2组患者的中医症状积分较治疗前均有明显下降,2组治疗前后胃肠道症状比较差异有统计学意义(P<0.05或P<0.01)。2组比较,血清CRP、血清补体C3、血淀粉酶差异均有统计学意义:治疗前2组血淀粉酶(AMY)明显高于正常值,治疗后2组AMY明显下降,治疗组恢复至正常值。2组治疗后血淀粉酶差值比较有统计学意义;治疗后2组CRP比较差异有统计学意义(P<0.01);2组治疗前C3、C4均有所上升,且2组比较差异无统计学意义;治疗后C3、C4恢复至正常水平,其中2组C3比较差异有统计学意义(P<0.05)。2组治疗前评分值均接近重症急性胰腺炎的评分标准(APACHEⅡ评分≥8分),经治疗后2组均有明显下降。[结论]清下化瘀方结合西药常规治疗急性胰腺炎,对其胃肠道及免疫功能有良好的保护作用。
[Objective] To evaluate the protective effect of Qingxia Huayu Recipe combined with routine western medicine on gastrointestinal tract and immune function of acute pancreatitis. [Method] The 65 patients with acute pancreatitis were divided into treatment group (32 cases) and control group (33 cases). Among them, the control group was given western medicine routine treatment, and the treatment group added Qingxia Huayu prescription on the basis of routine treatment of western medicine. After 7 days of treatment, the function of APACHEⅡscore was evaluated by observing the degree of relief of clinical symptom scores and monitoring of serum amylase, CRP and complement C3 / C4. [Results] The TCM symptom scores of two groups after treatment were significantly lower than those before treatment. There was significant difference in gastrointestinal symptoms between the two groups before and after treatment (P <0.05 or P <0.01). 2 groups, serum CRP, serum complement C3, serum amylase were significant differences: two groups before treatment serum amylase (AMY) was significantly higher than normal, 2 AMY group decreased after treatment, the treatment group returned to normal value. After 2 treatment group serum amylase enzyme statistically significant difference; CRP difference was statistically significant after 2 treatment groups (P <0.01); 2 Before treatment, C3, C4 are on the rise, and no difference between two groups Statistical significance; after treatment, C3, C4 returned to normal levels, of which two groups of C3 was statistically significant difference (P <0.05). The scores of two groups before treatment were all close to those of severe acute pancreatitis (APACHEⅡ score≥8), and both groups had a significant decrease after treatment. [Conclusion] Qingxiahuayu Recipe combined with western medicine routine treatment of acute pancreatitis has good protective effect on gastrointestinal tract and immune function.