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目的：探讨奥氮平与利培酮治疗精神分裂症患者的临床效果及对生活质量的影响。方法选取2012年4月至2013年3月我院收治的精神分裂症患者92例，随机分为奥氮平组及利培酮组各46例，分别采用奥氮平及利培酮治疗。比较两组临床有效率、PANSS评分、GQOLI评分及不良反应发生情况。结果奥氮平组与利培酮组有效率、不良反应发生率差异无统计学意义（P＞0.05）。两组治疗后阳性症状、阴性症状、一般精神病理及总分均降低，躯体健康、心理健康、社会功能评分均升高，差异有统计学意义（P＜0.05），治疗后两组PANSS各项评分、GQOLI各维度评分差异无统计学意义（P＞0.05）。结论奥氮平及利培酮治疗精神分裂症患者临床效果显著，不良反应发生率低且程度轻微，有利于提高患者的生活质量。“,”Objective To investigate the clinical effect of olanzapine and risperidone in the treatment of patients with schizophrenia and impact on quality of life. Methods 92 patients with schizophrenia were selected from April 2012 to March 2013 in our hospital, al of them were randomly divided into olanzapine group and risperidone group, each group had 46 cases, respectively, used olanzapine and risperidone for treatment. Compared two clinical efficiency, PANSS score, GQOLI score and adverse events. Results Olanzapine and risperidone group efficiency, incidence of adverse reactions was no significant difference(P>0.05).After treatment, positive symptoms, negative symptoms and general psychopathology scores were lower, physical health, mental health, social functioning scores were higher, the difference was statistical y significant(P 0.05). Conclusion The clinical effects of olanzapine and risperidone in the treatment of patients with schizophrenia significantly, and a low incidence of adverse reactions were mild, wil help improve the quality of life of patients.