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目的:对老年糖尿病高血压合并高尿酸血症患者采用厄贝沙坦联合苯磺酸氯地平治疗,探讨其临床疗效。方法:选取2014年3月至2015年3月本院接诊的98例老年糖尿病高血压合并高尿酸血症患者作研究对象,依据数字表法将其随机分为观察组与对照组,各49例,观察组患者予以厄贝沙坦联合苯磺酸氯地平治疗,对照组患者单独予以厄贝沙坦治疗。观察两组患者用药后的治疗效果以及治疗前后血尿酸水平的变化情况。结果:观察组患者治疗总有效率98.0%明显高于对照组79.6%,差异具有统计学意义(P<0.05);两组患者治疗前血尿酸水平相差不大,差异均无统计学意义(P>0.05),观察组患者治疗后血尿酸水平(352.6±34.5)μmol/L明显低于对照组(367.4±37.6)μmol/L,两组比较,差异具有统计学意义(P<0.05)。结论:采用厄贝沙坦联合苯磺酸氯地平治疗老年糖尿病高血压合并高尿酸血症患者具有较高的临床疗效,血压及血尿酸水平得到更好的控制。
OBJECTIVE: To investigate the clinical efficacy of irbesartan combined with chlorpheniramine besylate in elderly patients with diabetes mellitus and hyperuricemia. Methods: From March 2014 to March 2015, 98 elderly hypertensive patients with hypertension and hyperuricemia admitted to our hospital were enrolled in this study. Patients were randomly divided into observation group and control group according to digital table method For example, patients in the observation group were treated with irbesartan and chlorpheniramine besylate, and patients in the control group were treated with irbesartan alone. The therapeutic effect of the two groups after treatment and the change of serum uric acid level before and after treatment were observed. Results: The total effective rate of observation group was 98.0%, which was significantly higher than that of control group (79.6%), the difference was statistically significant (P <0.05). There was no significant difference between the two groups before treatment > 0.05). The level of serum uric acid (352.6 ± 34.5) μmol / L in the observation group was significantly lower than that in the control group (367.4 ± 37.6) μmol / L after treatment. There was significant difference between the two groups (P <0.05). Conclusion: The combination of irbesartan and clodipine besilate in the treatment of senile diabetic hypertensive patients with hyperuricemia has higher clinical efficacy, blood pressure and serum uric acid levels are better controlled.