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目的：探讨甲氨蝶呤（ｍｅｔｈｏｔｒｅｘａｔｅ，ＭＴＸ）与米非司酮（ｍｉｆｅｐｒｉｓｔｏｎｅ，Ｒｕ４８６）治疗异位妊娠的效果。方法：对确诊为异位妊娠胚胎存活的４４例患者进行药物保守治疗。随机分为两组，Ⅰ组：肌肉注射ＭＴＸ２０ｍｇ／ｄ，连用５天为１疗程。Ⅱ组：口服Ｒｕ４８６１００ｍｇ／ｄ，分２次，连用３天为１疗程。用药前、后定时测β－ｈｃＧ。结果：Ⅰ组总成功率９６．６７％，Ⅱ组总成功率６４．２８％。经四格表显著性检验，两组成功率有显著性差异（Ｐ＜０．０５）。结论：用药物保守治疗异位妊娠，ＭＴＸ明显优于Ｒｕ４８６。
Objective: To investigate the effect of methotrexate (MTX) and mifepristone (Ru486) on ectopic pregnancy. Methods: Forty-four patients diagnosed as ectopic pregnancy survived were treated conservatively. Randomly divided into two groups, Ⅰ group: intramuscular MTX20mg / d, once every 5 days for a course of treatment. Group Ⅱ: oral Ru486100mg / d, divided into 2 times, once every 3 days for a course of treatment. Β-hcG was measured regularly before and after treatment. Results: The total success rate of group Ⅰ was 96.67% and the total success rate of group Ⅱ was 64.28%. The four tables significant test, the success rate of the two groups were significantly different (P <0.05). Conclusion: With conservative treatment of ectopic pregnancy, MTX is significantly better than Ru486.