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甾体避孕药在我国用于临床已有三十余年,多年来的临床、实验室观察积累了许多有关其有效性、副作用等方面的数据,但关于长期服用甾体避孕药对遗传学方面影响的报道很少,为保汪该药长期服用的安全性,我们观察了它对人体淋巴细胞染色体的影响。实验选择连续服用甾体避孕药5～15年的健康农村妇女为对象,并以经济、文化、居住环境等条件相同的使用IUD 的妇女为对照,以外周血淋巴细胞微核出现率为指标,观察不同年龄和服药时间对染色体的损伤。
Steroid contraceptives have been used clinically for more than thirty years in our country. Over the years, many clinical and laboratory observations have accumulated a great deal of data about their effectiveness and side effects. However, the long-term use of steroid contraceptives in genetics Few reports of influence, to ensure the safety of the drug long-term use of the drug, we observed its impact on human lymphocyte chromosomes. The experiment selected healthy rural women who took steroid contraceptives continuously for 5 ~ 15 years as the object, and compared the women who used IUD with the same economic, cultural and living conditions as the control, taking the appearance rate of peripheral blood lymphocyte micronucleus as an index, Chromosomes were observed for different ages and doses.