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目的:研究硬骨鱼紧张素ⅡT21M基因(UTS2-T21M)单核苷酸多态性(SNP)与东乡族原发性高血压(EH)的关系。方法:用PCR-RFLP及电泳分析法进行基因分型;SPSS软件分析各基因型与东乡族人群EH的相关性。结果:研究包括120例东乡族EH患者及102例正常人。EH患者与对照组间在基因型,等位基因频率上均有显著差异(P=0.021,0.014)。UTS2-T21M多态性,TT,TM,MM基因型的频率在病例组中分别40.0%,43.3%,16.7%;对照组相应基因型的频率为22.5%,55.0%,22.5%。T,M等位基因频率在病例组中分别61.7%,38.3%,对照组相应的等位基因频率为50.0%,50.0%。结论:UTS2-T21M基因多态性与东乡族人群EH相关。
Objective: To investigate the relationship between UTS2-T21M gene polymorphism (SNP) and Dongxiang’s essential hypertension (EH). Methods: Genotyping was performed by PCR-RFLP and electrophoresis. SPSS software was used to analyze the association between genotypes and EH in Dongxiang population. Results: The study included 120 Dongxiang EH patients and 102 normal controls. EH patients and control groups in the genotypes, allele frequencies were significantly different (P = 0.021, 0.014). The frequencies of UTS2-T21M polymorphism, TT, TM and MM genotypes were 40.0%, 43.3% and 16.7% in the case group respectively. The frequencies of the corresponding genotypes in the control group were 22.5%, 55.0% and 22.5% respectively. The frequencies of T and M alleles were 61.7% and 38.3% in the case group and 50.0% and 50.0% respectively in the control group. Conclusion: UTS2-T21M gene polymorphism is associated with EH in Dongxiang ethnic group.