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目的:评价阿仑膦酸钠对患者脊柱骨质疏松的临床疗效。方法:选取2012年3月—2015年3月间诊治的强直性脊柱炎骨质疏松患者100例,将其分为观察组50例和对照组50例;对照组患者给予维生素D治疗,观察组患者给予维生素D和阿仑膦酸钠治疗,治疗5疗程后评价两组患者的总有效率以及血清碱性磷酸酶、骨碱性磷酸酶、骨钙素、25(OH)D_3和3、4、5节腰椎骨矿含量(BMC)和骨密度(BMD)的变化情况。结果:观察组治疗后的总有效率为90.0%高于对照组为58.00%(P<0.05),BMC和BMD测得值高于对照组(P<0.05)。结论:采用阿仑膦酸钠治疗骨质疏松患者,可有效抑制骨质的吸收,增加骨密度,改善患者病情。
Objective: To evaluate the clinical efficacy of alendronate in patients with spine osteoporosis. Methods: One hundred patients with osteoporotic ankylosing spondylitis who were diagnosed and treated between March 2012 and March 2015 were selected and divided into observation group (50 cases) and control group (50 cases). Patients in the control group were given vitamin D treatment and observation group Patients were given vitamin D and alendronate sodium treatment, after 5 courses of treatment to evaluate the total effective rate of two groups of patients and serum alkaline phosphatase, bone alkaline phosphatase, osteocalcin, 25 (OH) D_3 and 3,4 , 5 lumbar bone mineral content (BMC) and bone mineral density (BMD) changes. Results: The total effective rate of observation group after treatment was 90.0%, which was higher than that of control group (58.00%, P <0.05). The measured values of BMC and BMD were higher than those of control group (P <0.05). Conclusion: The use of alendronate in the treatment of osteoporosis patients can effectively inhibit bone absorption, increase bone mineral density and improve patient’s condition.