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用放射免疫法测定１８８例各型病毒性肝炎患者血清层粘连蛋白（ＬＮ）及Ⅳ型胶原（Ⅳ－Ｃ）。结果显示：①血清Ⅳ型胶原（Ⅳ－Ｃ）在重度慢性肝炎、肝炎后肝硬化和重型肝炎组明显增高；②血清ＬＮ在肝炎后肝硬化和重型肝炎组明显增高；③血清Ⅳ－Ｃ和ＬＮ的水平与血清丙种球蛋白呈正相关，与血清白蛋白呈负相关，与血清谷丙转氨酶无相关；④两项指标联合检测肝纤维化的检出率较单一项指标检出率要高；⑤血清Ⅳ型胶原（Ⅳ－Ｃ）在病毒性肝炎各组的检出率高于血清ＬＮ的检出率。提示血清Ⅳ－Ｃ和ＬＮ测定是一种较为可靠的肝纤维化的检测手段，两指标联合检测有利于提高肝纤维化的检出率
Serum laminin (LN) and type IV collagen (Ⅳ-C) were detected by radioimmunoassay in 188 patients with various types of viral hepatitis. The results showed that: (1) Serum type Ⅳ collagen (Ⅳ-C) was significantly increased in patients with severe chronic hepatitis, posthepatitic cirrhosis and severe hepatitis; ② Serum LN was significantly increased in patients with posthepatitic cirrhosis and severe hepatitis; ③Serum Ⅳ-C and The level of LN was positively correlated with serum gamma globulin, negatively correlated with serum albumin, and had no correlation with serum alanine aminotransferase. (4) The detection rate of liver fibrosis by the two indexes was higher than that of single index, ⑤ Serum type Ⅳ collagen (Ⅳ-C) in the detection of viral hepatitis in each group was higher than the detection rate of serum LN. It is suggested that the serum level of IV-C and LN is a more reliable method for the detection of liver fibrosis. The combined detection of two indexes is helpful to improve the detection rate of liver fibrosis