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对9例肾癌患者在行肾动脉造影的同行，经肾动脉注入TNF和IL－2的混合液之后用明胶海绵碎块栓塞。栓塞后4天行二期患肾切除术，切除的肾癌标本多处切片做病理检查，并与单纯的肾动脉栓塞术的肾癌切片标本对照观察，发现用药组肿瘤细胞坏死范围、程度较对照组广，肿瘤组织中有较多的淋巴细胞和巨噬细胞浸润，而且肾静脉残端均为坏死的肿瘤细胞，从而为经肾动脉化疗治疗肾恶性肿瘤提供了一种新的治疗方法。
Nine patients with renal cell carcinoma underwent renal artery angiography counterparts, the renal artery was injected with a mixture of TNF and IL-2 with gelatin sponge fragments embolization. Four days after embolization, two cases of nephrectomy were performed. Multiple resections of renal cell carcinoma were performed pathological examination and compared with simple renal artery embolization of renal cell carcinoma specimens. It was found that the extent of tumor cell necrosis in the treatment group was more severe In the control group, there were more lymphocytes and macrophages infiltrating into the tumor tissue, and all the necrotic tumor cells in the renal vein were stained. This provided a new treatment for renal malignant tumors via renal artery chemotherapy.