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目的探讨C-erbB-2和表皮生长因子受体(EGFR)与胃癌临床病理特征的关系。方法用免疫组织化学法对胃癌手术切除瘤组织检测C-erbB-2和EGFR表达。结果C-erbB-2表达阳性率为6.73%(14/209),其表达与年龄、病变部位、病理类型、分化程度等密切相关(P<0.05);EGFR表达阳性率为40.67%(85/209),其表达与年龄密切相关(P<0.01),与其他病理因素均无明显关系(P>0.05);C-erbB-2和EGFR表达无明显关系(P>0.05)。结论C-erbB-2的表达与胃癌的生物学行为有一定的相关性,但与EGFR表达无明显关系。
Objective To investigate the relationship between C-erbB-2 and epidermal growth factor receptor (EGFR) and clinicopathological features of gastric cancer. Methods Immunohistochemistry was used to detect the expression of C-erbB-2 and EGFR in resected gastric cancer tissue. Results The positive rate of C-erbB-2 expression was 6.73% (14/209). The expression of C-erbB-2 was closely related to age, pathological type, The expression of C-erbB-2 was not correlated with the expression of EGFR (P> 0.05). The expression of C-erbB-2 was not related to other pathological factors (P> 0.05). Conclusion The expression of C-erbB-2 is related to the biological behavior of gastric cancer, but not to the expression of EGFR.