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目的:探讨脆性组氨酸三联体(FHIT)、磷酸酶和张力蛋白同源基因(PTEN)在前列腺腺癌中的表达及其意义。方法:应用免疫组化PV-6000法对85例前列腺腺癌及30例良性前列腺增生(BPH)标本进行FHIT、PTEN检测。结果:FHIT、PTEN在前列腺腺癌组织中阳性表达率分别为34.1%、42.4%;在前列腺结节性增生组织中阳性表达率分别为96.7%、90.0%。前列腺腺癌组织中FHIT、PTEN阳性表达明显低于BPH,差异具有统计学意义(P<0.01)。FHIT、PTEN在前列腺腺癌Gleason分级为高分化组内阳性表达率分别为44.4%、55.6%;中分化组内阳性表达率分别为38.9%、44.4%;低分化组内阳性表达率分别为25.0%、37.5%。FHIT、PTEN阳性表达率在前列腺腺癌高分化、中分化、低分化组别之间有差异,差异亦有统计学意义(P<0.05)。前列腺腺癌组织中FHIT的表达与PTEN的表达无明显相关性(P>0.05)。结论:FHIT和PTEN在前列腺腺癌发生、发展、浸润的过程可能发挥了一定作用。
Objective: To investigate the expression and significance of FHIT, PTEN and PTEN in prostatic adenocarcinoma. Methods: Immunohistochemical PV-6000 method was used to detect FHIT and PTEN in 85 cases of prostatic adenocarcinoma and 30 cases of benign prostatic hyperplasia (BPH). Results: The positive expression rate of FHIT and PTEN in prostate adenocarcinoma was 34.1% and 42.4%, respectively. The positive rates of FHIT and PTEN in the prostatic adenocarcinoma were 96.7% and 90.0% respectively. Prostatic adenocarcinoma FHIT, PTEN positive expression was significantly lower than BPH, the difference was statistically significant (P <0.01). The positive rates of FHIT and PTEN were 44.4% and 55.6% respectively in the Gleason grade of well-differentiated group and 38.9% and 44.4% respectively in the moderately differentiated group. The positive expression rates of FHIT and PTEN in poorly differentiated group were 25.0% %, 37.5%. The positive rates of FHIT and PTEN were significantly different in well-differentiated, moderately differentiated and poorly differentiated groups of prostate adenocarcinoma (P <0.05). There was no significant correlation between FHIT expression and PTEN expression in prostatic adenocarcinoma (P> 0.05). Conclusion: FHIT and PTEN may play a role in the occurrence, development and invasion of prostatic adenocarcinoma.