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为加强盐酸莫西沙星的质量控制,合成了可能存在的3个有关物质:1-环丙基-6-氟-7-氨基-8-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸、1-环丙基-6-氟-1,4-二氢-8-甲氧基-7-[(S,S)-2-甲基-2,8-二氮杂双环[4.3.0]壬烷-8-基]-4-氧代-3-喹啉羧酸和1-环丙基-7-(1-氨基-8-氮杂双环[4.3.0]壬烷-8-基)-6-氟-8-甲氧基-1,4-二氢-4-氧代-3-喹啉羧酸,并经MS和1H NMR确证结构。
To enhance the quality control of moxifloxacin hydrochloride, three related substances that may exist were synthesized: 1-cyclopropyl-6-fluoro-7-amino-8-methoxy-4-oxo-1,4-bis 3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7 - [(S, S) -2-methyl- Diazabicyclo [4.3.0] nonan-8-yl] -4-oxo-3-quinolinecarboxylic acid and 1-cyclopropyl-7- (1-amino-8-azabicyclo [4.3. 0] nonan-8-yl) -6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and the structure was confirmed by MS and 1H NMR.