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肝纤维化的发生机制复杂，涉及细胞、生物因子等多种因素。肿瘤坏死因子作为免疫调节介质，在肝纤维化发生过程中起重要作用。
The mechanism of liver fibrosis is complicated, involving many factors such as cells and biological factors. Tumor necrosis factor plays an important role in the pathogenesis of hepatic fibrosis as an immunomodulatory mediator.